Tom Koehnle

Assistant Professor of Biology

B.S. The Ohio University
Ph.D. The University of California, Davis

Colton 205A
(330) 569-5316
koehnletj@hiram.edu

Research Interests
    Do you believe in love at first sight? Have you ever been scared out of your shoes? Did you ever wonder why scary music adds suspense to movies? Why are some people very shy or reserved, while others seek endless thrills? A quickening of the pulse, butterflies in your stomach, or gasping for breath are hallmarks of love, fear, and excitement. My fundamental research interest is in understanding how these processes work.

    Sensory feedback from the body, in a process called "interoception," shapes our personality, our emotions, our learning, and our decisionmaking. My priorities are 1) To understand how interoception shapes animal behavior (including the behavior of people), 2) To understand the neuroanatomical substrates and physiological systems that support these behaviors, 3) To understand the development of these substrates and systems, across both normal and abnormal life experiences.

    Currently I am focused on understanding how interoception shapes animal behavior. As part of this work, I am conducting a research project to determine whether behavioral reactivity in rodents is stable across time and across different types of situation. In this research I am examining harm-avoidance and novelty-seeking behaviors in wild rats. Basically, that means we expose a bunch of rats to novel or potentially threatening stimuli, and see what's happening inside their brains. Students wanting to work in my lab should love rodents (but not too much) and old barns.

    My studies span multiple levels of analysis, from looking at behavior of animals in the field to understanding the neuroanatomy and physiology that supports this behavior. This is probably the only lab on campus where you'll learn to use both a chainsaw and a microtome. Some day's you'll smell like formaldehyde, other days you'll smell like DEET. Ah, the joys of research!

    So why bother with any of this stuff? It's because alterations in the anatomy and function of interoceptive brain circuits have been linked to an array of psychiatric disorders in humans, including anxiety, depression, post-traumatic stress disorder, and functional bowel disorders. If we learn how these brain circuits work in animals, it will help us to understand how they work in people, and may lead to better treatments for a number of diseases and disorders.

Education
    B.S. in Biological Sciences from The Ohio University, 1998
    Ph.D. in Animal Behavior from The University of California, Davis, 2004
    Post Doctoral Scholar, Functional Neuroanatomy, University of Pittsburgh, 2004-2007.


Quasi-Academic Hobbies
    Science Fiction and Fantasy, especially Ellison, Borges, and Pratchett.
    History of almost any stripe, but especially the history of technology.

    Statistics, particularly the history and application of different methods and models (I'm currently researching the history of educational assessment).
    Early Christian theology, from Enoch and its predecessors through the first Council of Nicea.

 

Teaching Experience
Assistant Professor of Biology, Hiram College, 2007 - Present
    Human Anatomy and Physiology

Post Doctoral Scholar, University of Pittsburgh, 2004 - 2007
    Experimental Design and Data Analysis for Neuroscience
    Mentor for 2 undergraduate research projects

Graduate Instruction, UC Davis, 1998 - 2004
    Physiological Psychology
    Developmental Psychobiology
    Graduate Statistics
    Mentored 2 undergraduate research projects.

 

Research Publications
Koehnle, T.J. and Rinaman, L. (2007) Progressive postnatal increases in Fos
    immunoreactivity in the forebrain and brainstem of rats after viscerosensory
    stimulation with lithium chloride. American Journal of Physiology: Regulatory,
    Integrative, and Comparative Physiology
.
292: R1212-R1223.
 
Schank, J.C., Koehnle, T.J. (Accepted) Pseudoreplication is a pseudo-problem.
    Journal of Comparative Psychology.

Koehnle, T.J. (2005) The proof is not in the p-value. American Journal of
   
Physiology: Regulatory, Integrative, and Comparative Physiology
. 288: R777.


Hao, S., Sharp, J.W., Ross, C.M., McDaniel, B.J., Anthony, T.G., Wek,    
    R.C., Cavener, D.R., McGrath, B.C., Rudell, J.B., Koehnle, T.J., Gietzen, D.W.    
   
(2005) Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform
     cortex. Science. 307: 1776-1778.


Koehnle, T.J., Stephens, A., & Gietzen, D.W. (2004) Threonine imbalanced
    diet alters first meal microstructure in rats. Physiology & Behavior. 81: 15-21.
 
Koehnle, T.J., Russell, M.C., Morin, A.S., Erecius, L.F., Gietzen, D.W. (2004)
    Diets deficient in indispensable amino acids rapidly decrease the
    concentration of the limiting amino acid in the anterior piriform cortex
    of rats. Journal of Nutrition 134: 2365-2371.
 
Sharp, J.W., Ross, C.M., Koehnle, T., Gietzen, D.W. (2004) Phosphorylation
    of Ca2+/ calmodulin-dependent protein kinase type II and the AMPA
    receptor in response to a threonine-devoid diet. Neuroscience. 126: 1053-1062.
 
Koehnle, T.J., Russell, M.C. & Gietzen, D.W. (2003) Rats rapidly reject diets
    deficient in essential amino acids. Journal of Nutrition 133: 2331-2335.
 
Russell, M.C., Koehnle, T.J., Barrett, J.A., Blevins, J.E., & Gietzen, D.W.
    (2003) The rapid anorectic response to a threonine imbalanced diet is
    decreased by injection of threonine into the anterior piriform cortex of rats.
    Nutritional Neuroscience 6: 247-251.
 
Blais, A., Huneau, J-F., Magrum, L.J., Koehnle, T.J., Sharp, J.W., Tome, D.,
    & Gietzen, D.W. (2003) Threonine deprivation rapidly activates the
    System A amino acid transporter in primary cultures of rat neurons from
    the essential amino acid sensor in the anterior piriform cortex. Journal of
    Nutrition 133: 2156-2164.
 
Koehnle, T.J., & Schank, J.C. (2003) Power tools needed for the dynamical
    toolbox. Adaptive Behavior. 11: 291-293.
 
Koehnle, T.J., Brown, A. (1999) Slow axonal transport of neurofilament protein in
    cultured neurons. Journal of Cell Biology 144: 447-58.
 
Henley, W.N., Koehnle, T.J. (1997) Thyroid hormones and the treatment of
    depression: an examination of basic hormonal actions in the mature
    mammalian brain. Synapse 27: 36-44.
 
Book Chapters
L. Rinaman and T.J. Koehnle. (In Press) Development of Central Visceral Circuits. In:
    Handbook of Behavioral and Comparative Neuroscience: Epigenetics, Evolution, and
    Behavior, edited by M. Blumberg, J. Freeman, & S. Robinson, Oxford University Press.

Schank, J.C., Koehnle, T.J. (In Press) Modeling complex bio-behavioral systems.
    In: The Vienna Series in Theoretical Biology. MIT Press.


Koehnle, T.J., Gietzen, D.W. (2005) Modulation of feeding behavior by amino

    acid deficient diets: Present findings and future directions. In: Nutritional
    Neuroscience: Overview of an Emerging Field. Lieberman, H.R., Karnarek, R.B.,
    and Prasad, C. ed. Boca Raton: CRC Press. pp. 143-161